Frontline Plus for Dogs is a topical medication that works against tick and flea infestations. Its active ingredients, S-methoprene and fipronil, act to not only kill all existing ticks and fleas, but also work on flea eggs and larvae to ensure they don’t mature into adults. This medication is known to be 100% effective within the first 48 hours of application. Apart from this, Frontline Plus is also preferred by many due to its long lasting effect. Once applied, this medication can be effective for a whole month, even if you give your dog a bath or take him swimming. This is because fipronil accumulates in the animal’s sebaceous glands, from where it is constantly released onto the skin and coat.

Frontline Plus for Dogs is a safe medication and can be used on puppies and kittens as early as two days after birth. Although side effects of this medication are not common, they do occur and are mostly related to the alcohol used as a solvent.

Frontline Plus for Dogs: Side Effects to Watch Out For

If side effects occur after the use of Frontline Plus for Dogs, they will generally be related to skin effects. There are also side effects that have sometimes been seen to be neurological or mental in nature.

Skin related side effects

An immediate reaction your dog might have after the medication is applied is skin irritation. Itching and hair loss at the application site have also been reported in some dogs. Skin irritation usually manifests as redness or discoloration of the skin and itchiness. Most of the time, the side effect is temporary and goes away in a few days. However, if the irritation does not subside or appears to be more severe than before, you should immediately consult your veterinarian.

When skin irritation occurs, your dog will try to scratch the area. This will aggravate the condition. Therefore, keep an eye on your pet and avoid scratching, as scratching will spread the medication to their paws and other areas of their body, which they may lick. Scratching could also cause the area to bleed, which in turn could cause the medication to enter the bloodstream.

neurological side effects

Some of the neurological side effects could include:

  • increased drooling
  • Hypersensitivity to noise, light, or touch
  • Become quiet and appear depressed
  • aggressiveness and anxiety
  • elevated heart rate
  • Breathing or respiratory effects
  • Panting and vomiting have also been seen in some dogs, although this passes quickly.

If you notice any of these symptoms persisting in your pet, consult your veterinarian immediately.

Frontline Plus for Dogs: Effects on Humans and Other Species

Side effects in humans are rare. The most frequently reported effects are skin, mouth and eye irritation. If this occurs, immediately wash the affected area with plenty of clean water. The best way to avoid this effect is to apply Frontline Plus for Dogs just before bedtime and allow the medication to dry completely overnight before cuddling the dog. Do not let your dog sleep in your bed after applying the medication. Although severe reactions are extremely rare, humans may experience vomiting, agitation, and seizures. If such effects occur, you should immediately consult your doctor.

As for its effects on other species, the first thing to remember is not to apply Frontline Plus for Dogs to cats. This medication is available specifically for cats. This medication could be fatal to rabbits and aquatic species, so take care to prevent such species from coming into contact with the medication.

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